Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders
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چکیده
منابع مشابه
Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders
OBJECTIVE The diagnosis of mitochondrial disorders (MDs) is occasionally difficult because patients often present with solitary, or a combination of, symptoms caused by each organ insufficiency, which may be the result of respiratory chain enzyme deficiency. Growth differentiation factor 15 (GDF-15) has been reported to be elevated in serum of patients with MDs. In this study, we investigated w...
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Growth differentiation factor-15 (GDF15) is a member of the transforming growth factor beta superfamily and has been demonstrated to play multiple roles in various pathological conditions such as cancer, inflammatory diseases, cardiovascular diseases, and metabolic disorders. Furthermore, recent studies have shown that plasma levels of GDF15 increased in patients with chronic diseases described...
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BACKGROUND Growth differentiation factor-15 (GDF-15), a stress-responsive transforming growth factor-ß-related cytokine, is elevated and independently related to an adverse prognosis in systolic heart failure. OBJECTIVE This study aimed to investigate plasma levels of GDF-15 in patients with preclinical diastolic dysfunction or heart failure with normal ejection fraction (HFnEF). METHODS We...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2015
ISSN: 0364-5134,1531-8249
DOI: 10.1002/ana.24506